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18.1.3. Aberration of the Normals to the Surface A normal to the optical surface intersects the optical axis at a distance Zn from the vertex of the surface. To compute this distance, we need to know the value of the derivative of z with respect to S, which is given by dz cs 4A1 S3 6A2 S 5 8A3 S7 10A4 S 9 dS 1 K 1 c2 S2 1=2 The distance Zn is then given by Zn S z dz=dS 18:22 18:21

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0.001 5 10 4

getdata() returns a list of tuples representing each pixel in the image, and putdata(data, [,scale][, offset]) places a sequence of tuples into the image (the offset defaults to the beginning of the image, and the scale defaults to 1.0).

physician then performs data authoring supplied by the teleconsultation system and sends the images to the teleconsultation WS located at the expert site. This may be done through either the local area network if it is in the same building or campus, or through the wide area network if it is distant. Later either the general physician or an expert can call the other site to start the consultation session. The teleconsultation protocol has three steps: Data Formatting The rst step is to convert all input images for teleconsultation to the DICOM standard if they are not already DICOM. This is done at the acquisition gateway or at the PACS server. Data Authoring The authoring procedure is to prepare the image data for teleconsultation. The authoring module, TeleConApp, is an integrated component in the software package (inside the database manager module) Figure 15.15 shows the data authoring procedure. There are three steps in data authoring: 1. The general physician or radiologist uses the TeleConApp program to create an object called the virtual envelope, which includes information on the selected

mannitol infusion American Journal of Physiology, 254, R969 76 Tordoff, MG, Tluczek, JP and Friedman, MI (1989) Effect of hepatic portal glucose-concentration on food-intake and metabolism American Journal of Physiology, 257, R1474 80 Tschop, M, Smiley, DL and Heiman, ML (2000) Ghrelin induces adiposity in rodents Nature, 407, 908 13 Tso, P and Liu, M (2004) Apolipoprotein A-IV, food intake, and obesity Physiology & Behavior, 83, 631 43 Turnley, AM, Stapleton, D, Mann, RJ et al (1999) Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system Journal of Neurochemistry, 72 (4), 1707 16 Turrin, NP and Rivest, S (2004) Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems Experimental Biology and Medicine, 229, 996 1006 Turrin, NP, Gayle, D, Ilyin, SE.

(4.29) (4.30)

6.2.5 Sequential Assignment and Structure Elucidation The overall strategy for determining structure from 2-D NMR for proteins up to approximately 100 residues was developed by Kurt W trich in the early 1980s. More sophisu ticated NMR experiments suitable for larger proteins based on this overall approach were developed later and these are brie y described below. We can summarize the approach in four main steps (Figure 6.21): 1. Resonances in 2-D NMR spectra are assigned to individual amino acids in the sequence in a process called sequential resonance assignment. This involves a combination of COSY and NOESY experiments allowing the identi cation on the diagonal of such spectrum (i.e. 1 = 2 ) of resonances associated with speci c individual amino acids in the sequence. NOE interactions between adjacent residues in the sequence (e.g. NH (i + 1) with H (i)) are identi ed in this process and, for example, allow unambiguous identi cation of a speci c residue as being adjacent to two others, one on either side of it, in the primary structure.

accumulation and can cause hypoglycaemia; the latter induces intense hunger and, if recurrent, can signi cantly increase food intake. Sulphonylureas and meglitinide analogues, which are insulin secretagogues, act similarly. Thiazolidinediones cause weight gain through increased subcutaneous fat accumulation (PPAR activation promotes differentiation of preadipocytes in this depot). Sodium and water retention also occur, sometimes with clinical oedema; importantly, these drugs can precipitate cardiac failure. By contrast, drugs such as exenatide that enhance or mimic the action of GLP-1 (an insulin